Informatica, Python Add GUIs to your programs and scripts easily with PySimpleGUI 2 Settembre 2018 admin Few people run Python programs by double-clicking the .py file as if it were a .exe file. When a typical user (non-programmer types) double-clicks an .exe file, they expect it to pop open with a window they can interact with. While GUIs, using tkinter, are possible using standard Python installations, it’s unlikely many programs do this.